Figure 1

LY341495 produces a rapid antidepressant effect. (A) LY341495 produced a trend toward a reversal of stress-induced decreased sucrose preference at 24 hrs post-LY341495 treatment (not significant). (B) LY341495 reversed the stress-induced decrease in sucrose preference 48 hrs after a single treatment, indicating a rapid antidepressant effect. *P < 0.01 compared to No Stress/Vehicle; †P < 0.01 compared to Stress/Vehicle group; Stress x LY341495 interaction P = 0.05 (two-way ANOVA; LSD post-hoc tests).