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Table 1 Ontogenetic astrocyte progenitor pools

From: Astrocytes reassessment - an evolving concept part one: embryology, biology, morphology and reactivity

  Radial glia Postnatal glial progenitor cells Glial restricted precursors
Origin Neuroepithelial cells [1] • Radial glia [11, 12] Neuroepithelial cells skipping the radial glia stage [13, 14]
• Dlx2 (distal-less homeobox 2) [3]
• Local glial progenitors [1]
Location Ventricular zone [1] • Subventricular zone • Embryonic spinal cord [8] • Optic nerve [8]
• Dorso-lateral subventricular zone   
• Marginal zone [1, 11, 12]   
Characteristics Multipotential cells [11, 12] • Multipotential cells Tripotential cells [8] • Bipotential cells O-2A, O-2A/OPC [8, 15]
• Bipotential cells [3]   
Roles • Progenitors for neurons and glial cells • Intermediate progenitors for astrocytes and oligodendrocytes [3] • Promote neuroprotection • Tumor genesis (oligoastrocytomas, multiform glioblastomas) [15]
• Guidance of neuronal migration [11, 12]   • Reduction of glial scar  
   • Formation and axonal growth [8]  
Type of resulting astrocytes • Star shaped specialised cortical astrocytes • Cortical astrocytes • Self-renewal • Astrocytes type 2 and oligodendrocytes (in vitro)
  • White matter astrocytes • Astrocytes types 1, 2 and  
• Bergmann glia in the cerebellum [3, 16] • Oligodendrocytes [3] • Oligodendrocytes [8] • Oligodendrocytes (in vivo) [8, 15]