|
Origin
|
Neuroepithelial cells [1]
|
• Radial glia [11, 12]
|
Neuroepithelial cells skipping the radial glia stage [13, 14]
|
|
• Dlx2 (distal-less homeobox 2) [3]
|
|
• Local glial progenitors [1]
|
|
Location
|
Ventricular zone [1]
|
• Subventricular zone
|
• Embryonic spinal cord [8]
|
• Optic nerve [8]
|
|
• Dorso-lateral subventricular zone
| | |
|
• Marginal zone [1, 11, 12]
| | |
|
Characteristics
|
Multipotential cells [11, 12]
|
• Multipotential cells
|
Tripotential cells [8]
|
• Bipotential cells O-2A, O-2A/OPC [8, 15]
|
|
• Bipotential cells [3]
| | |
|
Roles
|
• Progenitors for neurons and glial cells
|
• Intermediate progenitors for astrocytes and oligodendrocytes [3]
|
• Promote neuroprotection
|
• Tumor genesis (oligoastrocytomas, multiform glioblastomas) [15]
|
|
• Guidance of neuronal migration [11, 12]
| |
• Reduction of glial scar
| |
| | |
• Formation and axonal growth [8]
| |
|
Type of resulting astrocytes
|
• Star shaped specialised cortical astrocytes
|
• Cortical astrocytes
|
• Self-renewal
|
• Astrocytes type 2 and oligodendrocytes (in vitro)
|
| |
• White matter astrocytes
|
• Astrocytes types 1, 2 and
| |
|
• Bergmann glia in the cerebellum [3, 16]
|
• Oligodendrocytes [3]
|
• Oligodendrocytes [8]
|
• Oligodendrocytes (in vivo) [8, 15]
|
