Figure 3
From: Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis
The genomic location and promoter region of the dopamine D5 receptor gene ( DRD5). (A) Chromosomal position of the DRD5 (from http://www.ensembl.org/index.html), which showed significantly increased methylation (p < 0.01) following olanzapine treatment. (B) Sequence of the promoter region of DRD5, with CTCF transcription factor binding sites highlighted in blue (identified using CTCFBSDB version 2.0 by Bao et al. Nucleic Acids Research 2008; 36, D83-D87). The frequency of A/C/G/T in the promoter sequence was 0.174/0.308/0.370/0.148, respectively. The CpG count in the promoter region was 50 out of 250 bp.