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Table 2 Candidate genes of the dopamine pathway, showing significantly increased methylation (p< 0.01 ) following olanzapine treatment in hippocampus, cerebellum and liver, in a rat model in vivo

From: Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis

Gene name Accession Chr. Strand TSS TTS EH-CH EC-CC EL-CL
Drd5 NM_012768 chr14 - 77769487 77768059 1 1 1
Camkk2 NM_031338 chr12 + 34772493 34938479 1   1
Calm3 NM_012518 chr1 - 77252717 77245608 1   
Kcnj2 NM_017296 chr10 + 100574984 100576268 1   
Kcnj4 NM_053870 chr7 - 117603827 117601722 1   
Cacna1c NM_012517 chr4 - 155517389 154895690 1   
Ppp3ca NM_017041 chr2 + 234130175 234409232 1   1
Adcy3 NM_130779 chr6 + 27118324 27202275 1   
Plcd1 NM_017035 chr8 - 124052193 124023089 1   
Ppp2r2d NM_144746 chr1 + 198640770 198674758 1   
Ppp1r1b NM_138521 chr10 + 87121888 87131587 1   
Nos1 NM_052799 chr12 - 39869484 39811720 1   
Itpr1 NM_001007235 chr4 + 143705359 144030051 1   
Ppp1r14b NM_172045 chr1 + 209648656 209650767 1   
Crem NM_001110860 chr17 + 62770632 62837670 1   
Slc18a2 NM_013031 chr1 + 265789916 265824551   1  
Ddc8 NM_001017481 chr10 - 108349394 108336343   1  
Drd2 NM_012547 chr8 + 52641159 52707749    1
Drd1a NM_012546 chr17 + 16655925 16658161    1
  1. Chr chromosome, TSS transcription start site, TTS transcription termination site, EH-CH, EC-CC, EL-CL the number of differentially enriched peaks that showed increased in methylation in Olanzapine treated experimental (E) rats as compared to matched-controls (C) in hippocampus (H), cerebellum (C) and liver (L), respectively.