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Table 1 Genes possibly involved in suicide

From: The neurobiology of suicide - A Review of post-mortem studies

Gene symbol Description Change Location Diagnosis Reference
A2M alpha-2-macroglobulin upregulation PFC SCH 35
ABCG2 ATP-binding cassette, sub-family G(WHITE), member 2 upregulation PFC aSCH 35
ADCY8 adenylate cyclase 8 (brain) upregulation LS MD 27
ADRA2A adrenoceptor alpha 2A higher frequency of the C1291G SNP G upregulated 73, 115
ADRA2B adrenoceptor alpha 2B higher frequency of the rs1018351 SNP G NC 116
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) downregulation PFC SCH 35
AGXT2L1 alanine-glyoxylate aminotransferase 2-like 1 downregulation PFC SCH 35
AHCYL1 S-adenosylhomocysteine hydrolase-like 1 downregulation PFC SCH 35
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 downregulation PFC SCH 35
APLP2 amyloid beta (A4) precursor-like protein 2 upregulation L MD 27
APOE Apolipoprotein E downregulation PFC SCH 35
APOLD1 apolipoprotein L domain containing 1 downregulation PFC SCH 35
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide downregulation PFC SCH 35
ATP1B2A ATPase, Na+/K+ transporting, beta 2 polypeptide downregulation PFC SCH 35
BACE1 beta-site APP-cleaving enzyme 1 upregulation LS MD 27
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 downregulation PFC SCH 35
BDNF brain-derived neurotrophic factor downregulatoin PFC, HIP NC 173, 174
C3 complement component 3 upregulation PFC SCH 35
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain upregulation PFC SCH 35
CDCA7L cell division cycle associated 7-like not characterised PFC NC 34
CDH12 cadherin 12, type 2 (N-cadherin 2) not characterised PFC NC 34
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) downregulation PFC BD 35
CLDN10 claudin 10 downregulation PFC SCH 35
COMT catechol-O-methyltransferase higher frequency of the val158met SNP G NC, male suicides only 125
CRH corticotropin releasing hormone upregulation PFC SCH 35
CSF1R colony stimulating factor 1 receptor upregulation PFCS CH 35
CX3CR1 chemokine (C-X3-C motif) receptor 1 upregulation PFC SCH 35
DARPP-32 protein phosphatase 1, regulatory (inhibitor) subunit 1B downregulation PFC SCH 128
DDIT4 DNA-damage-inducible transcript 4 downregulation PFC SCH 35
DUSP6 dual specificity phosphatase 6 upregulation PFC SCH 35
EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 downregulation PFC SCH 35
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 not characterised PFC NC 34
EIF5A eukaryotic translation initiation factor 5A downregulation PFC SCH 35
EMX2 empty spiracles homolog 2 (Drosophila) downregulation PFC SCH 34, 35
EMX2 empty spiracles homolog 2 (Drosophila) downregulation PFC BD 35
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) downregulation PFC SCH 35
EVC Ellis van Creveld syndrome higher frequency of the rs1383180 polymorhism G NC, male suicides only 26
FAM107A family with sequence similarity 107, member A downregulation PFC SCH 35
FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) downregulation PFC SCH 35
FXYD1 FXYD domain containing ion transport regulator 1 (phospholemman) downregulation PFC SCH 35
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 upregulation LS MD 27
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 upregulation PFC BD 34, 35
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 upregulation LS MD 27
GLUL glutamate-ammonia ligase (glutamine synthetase) downregulation PFC SCH 35
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 upregulation PFC SCH 35
HLA-DRA major histocompatibility complex, class II, DR alpha upregulation PFC SCH 35
HSPB1 heat shock 27 kDa protein 1 downregulation PFC SCH 35
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled higher frequency of the Cys23Ser polymorhism G NC, female suicides only 84
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein downregulation PFC SCH 36
IL17RB interleukin 17 receptor B downregulation PFC SCH 35
ITGB4 integrin, beta 4 downregulation PFC SCH 35
ITPKB inositol 1,4,5-trisphosphate 3-kinase B downregulation PFC SCH 35
LAPTM5 lysosomal associated multispanning membrane protein 5 upregulation PFC SCH 35
LDLR low density lipoprotein receptor downregulation PFC BD 35
LOC645745 metallothionein 1H-like protein downregulation PFC SCH 35
lTrkB neurotrophic tyrosine kinase, receptor, type 2 downregulation PFC, HIP NC 171
METTL7A methyltransferase like 7A downregulation PFC SCH 35
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 downregulation PFC SCH 35
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 not characterised PFC NC 34
MT1E metallothionein 1E (functional) downregulation PFC SCH 35
MT1F metallothionein 1F (functional) downregulation PFC SCH 35
MT1G metallothionein 1G dcownregulation PFC SCH 35
MT1H metallothionein 1H downregulation PFC SCH 35
MT1M metallothionein 1M downregulation PFC SCH 35
MT1X metallothionein 1X downregulation PFC SCH 35
NAV2 neuron navigator downregulation PFC BD 35
NDRG2 NDRG family member 2 downregulation PFC SCH 35
NOTCH2 Notch homolog 2 (Drosophila) downregulation PFC SCH 35
NPY neuropeptide Y upregulation PFC SCH 35
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 downregulation PFC SCH 35
NTSR2 neurotensin receptor 2 downregulation PFC SCH 35
P2RY13 purinergic receptor P2Y, Gprotein coupled, 13 upregulation PFC SCH 35
p75NTR (NGFR) nerve growth factor receptor higher frequency of the missense polymorphism (S205L) G MD 23
PCDHB5 protocadherin beta 5 NC PFC NC 34
PLSCR4 phospholipid scramblase 4 downregulation PFC SCH 34, 35
PLSCR4 phospholipid scramblase 4 downregulation PFC BD 35
PPAP2B phosphatidic acid phosphatase type 2B downregulation PFC SCH 35
PRKCI protein kinase C, iota upregulated PFC NC 150
PTPRR protein tyrosine phosphatase, receptor type, R downregulation PFC NC 34
RAB31 RAB31, member RAS oncogene family downregulation PFC SCH 35
RHOBTB34 Rho-related BTB domain containing 3 downregulation PFC SCH 35
S100A13 S100 calcium binding protein A13 not characterised PFC NC 34
SAT1 spermidine/spermine N1-acetyltransferase 1 downregulation, higher frequency of the rs6526342 SNP PFC MD 186, 187, 188, 189, 190, 192
SCN2B sodium channel, voltage-gated, type II, beta subunit not characterised PFC NC 34
SDC2 syndecan 2 (heparan sulfate proteoglycan 1, cell surfaceassociated, fibroglycan) downregulation PFC SCH 35
SDC4 syndecan 4 (amphiglycan, ryudocan) downregulation PFC SCH 35
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) downregulation PFC SCH 35
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 downregulation PFC SCH 35
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 upregulation PFC SCH 35
SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 downregulation PFC SCH 35
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 higher frequency of the rs403636 SNP G NC 116
SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+system) member 11 downregulation PFC SCH 35
SOX9 SRY (sex determining region Y)-box 9 downregulation PFC SCH 35
SPON1 spondin 1, extracellular matrix protein downregulation PFC SCH 35
STCH stress 70 protein chaperone, microsome-associated, 60 kDa upregulation PFC BD 35
SYT4 synaptotagmin IV upregulation LS MD 27 TIMP1 TIMP metallopeptidase inhibitor 1 downregulation PFC BD 35
TM4SF1 transmembrane 4 L six family member 1 downregulation PFC BD 35
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 upregulation PFC SCH 35
TP53BP2 tumor protein p53 binding protein, 2 downregulation PFC SCH 35
TPD52L1 tumor protein D52-like 1 downregulation PFC SCH 35
TPH2 tryptophan hydroxylase 2 higher frequeny of the rs1386494 SNP G NC 88
TRIM23 tripartite motif-containing 23 upregulation PFC BD 35
TUBB2B tubulin, beta 2B downregulation PFC SCH 35
TYROBP TYRO protein tyrosine kinase binding protein upregulation PFC SCH 35
VIL2 villin 2 (ezrin) downregulation PFCS CH 35
WFS1 Wolfram syndrome 1 (wolframin) higher frequency of the 611R/611R genotype G NC 21, 22
ZFP36 ZFP36 ring finger protein not characterised PFC NC 34
ZHX2 zinc fingers and homeoboxes 2 downregulation PFC BD 35
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) downregulation PFC BD 35