Table 1 Genes possibly involved in suicide

A2M

alpha-2-macroglobulin

upregulation

PFC

SCH

35

ABCG2

ATP-binding cassette, sub-family G(WHITE), member 2

upregulation

PFC

aSCH

35

ADCY8

adenylate cyclase 8 (brain)

upregulation

LS

MD

27

ADRA2A

adrenoceptor alpha 2A

higher frequency of the C1291G SNP

G

upregulated

73, 115

ADRA2B

adrenoceptor alpha 2B

higher frequency of the rs1018351 SNP

G

NC

116

AGT

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

downregulation

PFC

SCH

35

AGXT2L1

alanine-glyoxylate aminotransferase 2-like 1

downregulation

PFC

SCH

35

AHCYL1

S-adenosylhomocysteine hydrolase-like 1

downregulation

PFC

SCH

35

ALDH1L1

aldehyde dehydrogenase 1 family, member L1

downregulation

PFC

SCH

35

APLP2

amyloid beta (A4) precursor-like protein 2

upregulation

L

MD

27

APOE

Apolipoprotein E

downregulation

PFC

SCH

35

APOLD1

apolipoprotein L domain containing 1

downregulation

PFC

SCH

35

ATP1A2

ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide

downregulation

PFC

SCH

35

ATP1B2A

ATPase, Na+/K+ transporting, beta 2 polypeptide

downregulation

PFC

SCH

35

BACE1

beta-site APP-cleaving enzyme 1

upregulation

LS

MD

27

BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1

downregulation

PFC

SCH

35

BDNF

brain-derived neurotrophic factor

downregulatoin

PFC,

HIP NC

173, 174

C3

complement component 3

upregulation

PFC

SCH

35

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

upregulation

PFC

SCH

35

CDCA7L

cell division cycle associated 7-like

not characterised

PFC

NC

34

CDH12

cadherin 12, type 2 (N-cadherin 2)

not characterised

PFC

NC

34

CHI3L1

chitinase 3-like 1 (cartilage glycoprotein-39)

downregulation

PFC

BD

35

CLDN10

claudin 10

downregulation

PFC

SCH

35

COMT

catechol-O-methyltransferase

higher frequency of the val158met SNP

G

NC, male suicides only

125

CRH

corticotropin releasing hormone

upregulation

PFC

SCH

35

CSF1R

colony stimulating factor 1 receptor

upregulation

PFCS

CH

35

CX3CR1

chemokine (C-X3-C motif) receptor 1

upregulation

PFC

SCH

35

DARPP-32

protein phosphatase 1, regulatory (inhibitor) subunit 1B

downregulation

PFC

SCH

128

DDIT4

DNA-damage-inducible transcript 4

downregulation

PFC

SCH

35

DUSP6

dual specificity phosphatase 6

upregulation

PFC

SCH

35

EFEMP1

EGF-containing fibulin-like extracellular matrix protein 1

downregulation

PFC

SCH

35

EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

not characterised

PFC

NC

34

EIF5A

eukaryotic translation initiation factor 5A

downregulation

PFC

SCH

35

EMX2

empty spiracles homolog 2 (Drosophila)

downregulation

PFC

SCH

34, 35

EMX2

empty spiracles homolog 2 (Drosophila)

downregulation

PFC

BD

35

EPHX1

epoxide hydrolase 1, microsomal (xenobiotic)

downregulation

PFC

SCH

35

EVC

Ellis van Creveld syndrome

higher frequency of the rs1383180 polymorhism

G

NC, male suicides only

26

FAM107A

family with sequence similarity 107, member A

downregulation

PFC

SCH

35

FGFR3

fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

downregulation

PFC

SCH

35

FXYD1

FXYD domain containing ion transport regulator 1 (phospholemman)

downregulation

PFC

SCH

35

GABRA1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

upregulation

LS

MD

27

GABRA5

gamma-aminobutyric acid (GABA) A receptor, alpha 5

upregulation

PFC

BD

34, 35

GABRB1

gamma-aminobutyric acid (GABA) A receptor, beta 1

upregulation

LS

MD

27

GLUL

glutamate-ammonia ligase (glutamine synthetase)

downregulation

PFC

SCH

35

HLA-DPA1

major histocompatibility complex, class II, DP alpha 1

upregulation

PFC

SCH

35

HLA-DRA

major histocompatibility complex, class II, DR alpha

upregulation

PFC

SCH

35

HSPB1

heat shock 27 kDa protein 1

downregulation

PFC

SCH

35

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

higher frequency of the Cys23Ser polymorhism

G

NC, female suicides only

84

ID4

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

downregulation

PFC

SCH

36

IL17RB

interleukin 17 receptor B

downregulation

PFC

SCH

35

ITGB4

integrin, beta 4

downregulation

PFC

SCH

35

ITPKB

inositol 1,4,5-trisphosphate 3-kinase B

downregulation

PFC

SCH

35

LAPTM5

lysosomal associated multispanning membrane protein 5

upregulation

PFC

SCH

35

LDLR

low density lipoprotein receptor

downregulation

PFC

BD

35

LOC645745

metallothionein 1H-like protein

downregulation

PFC

SCH

35

lTrkB

neurotrophic tyrosine kinase, receptor, type 2

downregulation

PFC,

HIP NC

171

METTL7A

methyltransferase like 7A

downregulation

PFC

SCH

35

MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

downregulation

PFC

SCH

35

MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

not characterised

PFC

NC

34

MT1E

metallothionein 1E (functional)

downregulation

PFC

SCH

35

MT1F

metallothionein 1F (functional)

downregulation

PFC

SCH

35

MT1G

metallothionein 1G

dcownregulation

PFC

SCH

35

MT1H

metallothionein 1H

downregulation

PFC

SCH

35

MT1M

metallothionein 1M

downregulation

PFC

SCH

35

MT1X

metallothionein 1X

downregulation

PFC

SCH

35

NAV2

neuron navigator

downregulation

PFC

BD

35

NDRG2

NDRG family member 2

downregulation

PFC

SCH

35

NOTCH2

Notch homolog 2 (Drosophila)

downregulation

PFC

SCH

35

NPY

neuropeptide Y

upregulation

PFC

SCH

35

NTRK2

neurotrophic tyrosine kinase, receptor, type 2

downregulation

PFC

SCH

35

NTSR2

neurotensin receptor 2

downregulation

PFC

SCH

35

P2RY13

purinergic receptor P2Y, Gprotein coupled, 13

upregulation

PFC

SCH

35

p75NTR (NGFR)

nerve growth factor receptor

higher frequency of the missense polymorphism (S205L)

G

MD

23

PCDHB5

protocadherin beta 5

NC

PFC

NC

34

PLSCR4

phospholipid scramblase 4

downregulation

PFC

SCH

34, 35

PLSCR4

phospholipid scramblase 4

downregulation

PFC

BD

35

PPAP2B

phosphatidic acid phosphatase type 2B

downregulation

PFC

SCH

35

PRKCI

protein kinase C, iota

upregulated

PFC

NC

150

PTPRR

protein tyrosine phosphatase, receptor type, R

downregulation

PFC

NC

34

RAB31

RAB31, member RAS oncogene family

downregulation

PFC

SCH

35

RHOBTB34

Rho-related BTB domain containing 3

downregulation

PFC

SCH

35

S100A13

S100 calcium binding protein A13

not characterised

PFC

NC

34

SAT1

spermidine/spermine N1-acetyltransferase 1

downregulation, higher frequency of the rs6526342 SNP

PFC

MD

186, 187, 188, 189, 190, 192

SCN2B

sodium channel, voltage-gated, type II, beta subunit

not characterised

PFC

NC

34

SDC2

syndecan 2 (heparan sulfate proteoglycan 1, cell surfaceassociated, fibroglycan)

downregulation

PFC

SCH

35

SDC4

syndecan 4 (amphiglycan, ryudocan)

downregulation

PFC

SCH

35

SLC14A1

solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

downregulation

PFC

SCH

35

SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

downregulation

PFC

SCH

35

SLC25A23

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

upregulation

PFC

SCH

35

SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

downregulation

PFC

SCH

35

SLC6A3

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

higher frequency of the rs403636 SNP

G

NC

116

SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+system) member 11

downregulation

PFC

SCH

35

SOX9 SRY

(sex determining region Y)-box 9

downregulation

PFC

SCH

35

SPON1

spondin 1, extracellular matrix protein

downregulation

PFC

SCH

35

STCH

stress 70 protein chaperone, microsome-associated, 60 kDa

upregulation

PFC

BD

35

SYT4

synaptotagmin IV upregulation LS MD 27 TIMP1 TIMP metallopeptidase inhibitor 1

downregulation

PFC

BD

35

TM4SF1

transmembrane 4 L six family member 1

downregulation

PFC

BD

35

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

upregulation

PFC

SCH

35

TP53BP2

tumor protein p53 binding protein, 2

downregulation

PFC

SCH

35

TPD52L1

tumor protein D52-like 1

downregulation

PFC

SCH

35

TPH2

tryptophan hydroxylase 2

higher frequeny of the rs1386494 SNP

G

NC

88

TRIM23

tripartite motif-containing 23

upregulation

PFC

BD

35

TUBB2B

tubulin, beta 2B

downregulation

PFC

SCH

35

TYROBP

TYRO protein tyrosine kinase binding protein

upregulation

PFC

SCH

35

VIL2

villin 2 (ezrin)

downregulation

PFCS

CH

35

WFS1

Wolfram syndrome 1 (wolframin)

higher frequency of the 611R/611R genotype

G

NC

21, 22

ZFP36

ZFP36 ring finger protein

not characterised

PFC

NC

34

ZHX2

zinc fingers and homeoboxes 2

downregulation

PFC

BD

35

ZIC1

Zic family member 1 (odd-paired homolog, Drosophila)

downregulation

PFC

BD

35