From: The neurobiology of suicide - A Review of post-mortem studies
System element | Change | Location | ||
---|---|---|---|---|
SEROTONERGIC | Receptors | 5HT-1A | upregulated | RN, FC |
 | 5HT-1D | downregulated | PFC | |
 | 5HT-2A | downregulated | PFC, HIP, FPC | |
 | 5HT-2C | upregulated | PFC | |
 | 5-HT4 | upregulated | FC, HIP, CN, AN | |
Enzymes | TPH | upregulated | RN | |
 | Transporter | Serotonin transporter | downregulated | PFC, RN |
NORADRENERGIC | Receptors | Alpha-1 | downregulated | PFC, TC, CN |
Alpha-2 | upregulated in drug-free subjects | HIP, FC, LC, HTH | ||
downregulated in antidepressant- treated subjects | OC, HIP | |||
Alpha-2A | upregulated in drug-free subjects | EC, HTH, PEE | ||
downregulated in antidepressanttreated subjects | AN, CN | |||
Beta | upregulated | PFC, TC | ||
Alpha-2 ‘Beta ratio | increased | G | ||
Enzymes | TH | upregulated | LC | |
DOPAMINERGIC | Dopamine turnover | Dihydroxy- phenylacetic acid concentration | decreased | CN, P. NA |
GLUTAMATERGIC | Receptors | NMDA | downregulated | G |
Zinc inhibition decreased | HIP | |||
AMPA | upregulated | CN | ||
GABA-ERGIC | Receptors | GABA | upregulated | FC |
ENDOCANNABINOID | Receptors | CB(1) | upregulated | PFC |