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Table 2 Neurotransmitter systems and suicide

From: The neurobiology of suicide - A Review of post-mortem studies

System element

Change

Location

SEROTONERGIC

Receptors

5HT-1A

upregulated

RN, FC

 

5HT-1D

downregulated

PFC

 

5HT-2A

downregulated

PFC, HIP, FPC

 

5HT-2C

upregulated

PFC

 

5-HT4

upregulated

FC, HIP, CN, AN

Enzymes

TPH

upregulated

RN

 

Transporter

Serotonin transporter

downregulated

PFC, RN

NORADRENERGIC

Receptors

Alpha-1

downregulated

PFC, TC, CN

Alpha-2

upregulated in drug-free subjects

HIP, FC, LC, HTH

downregulated in antidepressant- treated subjects

OC, HIP

Alpha-2A

upregulated in drug-free subjects

EC, HTH, PEE

downregulated in antidepressanttreated subjects

AN, CN

Beta

upregulated

PFC, TC

Alpha-2 ‘Beta ratio

increased

G

Enzymes

TH

upregulated

LC

DOPAMINERGIC

Dopamine turnover

Dihydroxy- phenylacetic acid concentration

decreased

CN, P. NA

GLUTAMATERGIC

Receptors

NMDA

downregulated

G

Zinc inhibition decreased

HIP

AMPA

upregulated

CN

GABA-ERGIC

Receptors

GABA

upregulated

FC

ENDOCANNABINOID

Receptors

CB(1)

upregulated

PFC