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Table 2 Genotype distribution, genotype frequencies, and minor allele frequencies for autism spectrum disorder (ASD), siblings, and control groups

From: Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism

Polymorphism Genotype distribution (Genotype frequency) MAF (Allele)
HTTLPR triallelic 1 ss sl ll  
ASD 24 (0.316) 38 (0.500) 14 (0.184) 0.434 (l)
Siblings 16 (0.208) 43 (0.558) 18 (0.234) 0.487 (s)
Controls 22 (0.248) 51 (0.526) 24 (0.247) 0.490 (s)
HTR2A rs6311 2 GG GA AA A
ASD 21 (0.276) 34 (0.447) 21 (0.276) 0.500
Siblings 23 (0.295) 35 (0.449) 20 (0.256) 0.481
Controls 29 (0.299) 47 (0.485) 21 (0.216) 0.459
OXTR rs2301261 CC CT TT T
ASD 65 (0.855) 11 (0.145) 0 0.072
Siblings 67 (0.859) 11 (0.141) 0 0.071
Controls 84 (0.848) 15 (0.152) 0 0.076
OXTR rs53576 1 AA AG GG A
ASD 7 (0.092) 34 (0.447) 35 (0.461) 0.316
Siblings 7 (0.091) 37 (0.481) 33 (0.429) 0.331
Controls 9 (0.093) 33 (0.340) 55 (0.567) 0.263
OXTR rs2254298 AA AG GG A
ASD 0 12 (0.158) 64 (0.842) 0.079
Siblings 0 13 (0.167) 65 (0.833) 0.083
Controls 0 21 (0.212) 78 (0.788) 0.106
OXTR rs2268494 AA AT TT A
ASD 0 13 (0.171) 63 (0.829) 0.086
Siblings 1 (0.013) 9 (0.115) 68 (0.872) 0.071
Controls 0 17 (0.172) 82 (0.828) 0.086
  1. Abbreviations: ASD autism spectrum disorder, OXTR oxytocin receptor, HTR2A serotonin receptor 2A, HTTLPR serotonin-transporter–linked polymorphic region, MAF minor allele frequency. 1Genotyping failed repeatedly for one sibling and two controls. 2Genotyping failed repeatedly for two controls.