Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism

Table 3 Statistical association analysis between autism spectrum disorder (ASD) or its subgroups (atypical and Asperger) compared to controls or siblings with all six polymorphisms

	p values
Polymorphism	AA vs. controls	AS vs. controls	ASD vs. controls	ASD vs. siblings
Genotype frequencies
HTTLPR triallelic	0.926	0.110	0.350	0.301
HTR2A rs6311	0.720	0.299	0.661	0.949
OXTR rs2301261	0.595	0.731	0.901	0.948
OXTR rs53576	0.524	0.280	0.334	0.914
OXTR rs2254298	0.460	0.592	0.363	0.883
OXTR rs2268494	0.870	0.974	0.991	0.388
Allele frequencies
HTTLPR triallelic	0.708	0.040	0.160	0.168
HTR2A rs6311	0.591	0.410	0.446	0.736
OXTR rs2301261	0.609	0.743	0.905	0.950
OXTR rs53576	0.307	0.464	0.280	0.774
OXTR rs2254298	0.486	0.614	0.390	0.888
OXTR rs2268494	0.877	0.975	0.991	0.623
Carrier frequencies [Carrier]
HTTLPR triallelic [s]	0.787	0.108	0.319	0.451
HTTLPR triallelic [l]	0.725	0.073	0.189	0.129
HTR2A rs6311 [C]	0.949	0.158	0.362	0.780
HTR2A rs6311 [T]	0.433	0.948	0.744	0.799
OXTR rs53576 [G]	0.776	0.579	0.988	0.980
OXTR rs53576 [A]	0.258	0.216	0.164	0.691

In the subgroup analysis the three childhood autism were not included in either AA or AS subgroup. Abbreviations: AA atypical autism, AS Asperger syndrome, ASD autism spectrum disorder, OXTR oxytocin receptor, HTR2A serotonin receptor 2A, HTTLPR serotonin-transporter–linked polymorphic region, vs. versus, Bold nominal significant.

ISSN: 2049-9256