Gene symbol | Description | Gene function | Gene expression in IBS | Psychiatric diseases | Reference |
---|---|---|---|---|---|
NGF | Nerve growth factor | Pro-inflammatory mediator; psychoneuroendocrine modulator | Overexpression (in rat model) | Anxiety, chronic alcohol consumption, depression | |
BDNF | Brain-Derived Neurotrophic Factor | Regulation of stress response and in the biology of mood disorders | SNP | Psychiatric IBS, schizophrenia, mood disorders, PTSD | |
COMT | Catechol | Degradative pathways of the catecholamine transmitters; metabolism of catechol drugs | SNP | Anxiety, panic disorder, and cognitive performance | |
O-Methyltransferase | |||||
OPRM1 | Mu Opiate Receptor | Principal target of endogenous opioid peptides | SNP | Pain sensitivity, opioid dependence, and social sensitivity | |
5-HTTLPR | 5-hydroxytryptamine transporter gene-linked polymorphic region | Serotonin transporter | SNP | Depression, anxiety, rectal pain ratings |