Skip to main content

Table 1 Potential target genes associated with psychiatric diseases in IBS

From: The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

Gene symbol

Description

Gene function

Gene expression in IBS

Psychiatric diseases

Reference

NGF

Nerve growth factor

Pro-inflammatory mediator; psychoneuroendocrine modulator

Overexpression (in rat model)

Anxiety, chronic alcohol consumption, depression

[71, 72]

BDNF

Brain-Derived Neurotrophic Factor

Regulation of stress response and in the biology of mood disorders

SNP

Psychiatric IBS, schizophrenia, mood disorders, PTSD

[73, 74]

COMT

Catechol

Degradative pathways of the catecholamine transmitters; metabolism of catechol drugs

SNP

Anxiety, panic disorder, and cognitive performance

[75, 76]

O-Methyltransferase

OPRM1

Mu Opiate Receptor

Principal target of endogenous opioid peptides

SNP

Pain sensitivity, opioid dependence, and social sensitivity

[77, 78]

5-HTTLPR

5-hydroxytryptamine transporter gene-linked polymorphic region

Serotonin transporter

SNP

Depression, anxiety, rectal pain ratings

[79, 80]