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Table 1 Potential target genes associated with psychiatric diseases in IBS

From: The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

Gene symbol Description Gene function Gene expression in IBS Psychiatric diseases Reference
NGF Nerve growth factor Pro-inflammatory mediator; psychoneuroendocrine modulator Overexpression (in rat model) Anxiety, chronic alcohol consumption, depression [71, 72]
BDNF Brain-Derived Neurotrophic Factor Regulation of stress response and in the biology of mood disorders SNP Psychiatric IBS, schizophrenia, mood disorders, PTSD [73, 74]
COMT Catechol Degradative pathways of the catecholamine transmitters; metabolism of catechol drugs SNP Anxiety, panic disorder, and cognitive performance [75, 76]
O-Methyltransferase
OPRM1 Mu Opiate Receptor Principal target of endogenous opioid peptides SNP Pain sensitivity, opioid dependence, and social sensitivity [77, 78]
5-HTTLPR 5-hydroxytryptamine transporter gene-linked polymorphic region Serotonin transporter SNP Depression, anxiety, rectal pain ratings [79, 80]
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