Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features

Table 3 mRNA levels of the genes in schizophrenia subtypes

Variables	Paranoid (n = 32)	p^a	Catatonic (n = 17)	p^a	Disorganized (n = 39)	p^a	Undifferentiated (n = 26)	p^a	Residual (n = 24)	p^a	Statistical analysis
NDUFV1; Mean ± s.d	1.4 ± 1.3	0.5	1.6 ± 0.7	0.01	1.7 ± 1.6	0.02	1.5 ± 1.2	0.02	1.3 ± 0.6	0.08	X ² = 3.50; df = 2; p = 0.5
NDUFV2; Mean ± s.d	1.6 ± 1.2	0.2	2.1 ± 0.9	< 0.01	2.4 ± 1.9	< 0.01	1.7 ± 1.1	0.02	1.6 ± 1.8	0.1	X ² = 5.48; df = 2; p = 0.2
NDUFS1; Mean ± s.d	1.3 ± 0.8	0.4	1.9 ± 1.0	0.01	1.7 ± 0.8	0.01	1.6 ± 0.7	< 0.01	1.5 ± 1.2	0,.2	X ² = 4.10; df = 2; p = 0.4
UQCR10; Mean ± s.d	5.6 ± 13.5	0.6	12.9 ± 21.5	0.1	2.6 ± 4.2	0.7	1.8 ± 2.2	0.7	9.7 ± 24.8	0.2	X ² = 2.5; df = 2; p = 0.6

Mean ± s.d: Mean ± standart deviation X²: Kruskal Wallis test p^a : Compared with control group.
There was no significant difference in mRNA levels of schizophrenia subtypes. mRNA levels of complex I genes (NDUFV1, NDUFV2, NDUFS1) in catatonic, disorganized and undifferentiated types were significantly higher than control group.

ISSN: 2049-9256