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Table 1 The differences between voluntary and forced exercise in murine studies

From: Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations

Voluntary exercise Forced exercise
Self-selected cruising speed Researcher pre-prescribed speeds
Variable speeds Constant speeds
Short bursts of exercise Relatively long periods of exercise
No coercion of the animal Coercion of the animal
No psychological stress arising from coercion Possible psychological stress arising from coercion
No physiological cascades arising from psychological stress from coercion Possible physiological cascades arising from potential psychological stress from coercion
No potential for physiological responses to the psychological stress of coercion to interact with or confound the parameters under investigation Potential for physiological responses to the psychological stress of coercion to interact with or confound the parameters under investigation
No potential for confounded findings due to psychological stress physiology Potential for confounded findings due to physiological stress physiology
Directly translatable to clinical studies Difficulty with translation to clinical studies