Self-selected cruising speed
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Researcher pre-prescribed speeds
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Variable speeds
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Constant speeds
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Short bursts of exercise
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Relatively long periods of exercise
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No coercion of the animal
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Coercion of the animal
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No psychological stress arising from coercion
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Possible psychological stress arising from coercion
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No physiological cascades arising from psychological stress from coercion
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Possible physiological cascades arising from potential psychological stress from coercion
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No potential for physiological responses to the psychological stress of coercion to interact with or confound the parameters under investigation
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Potential for physiological responses to the psychological stress of coercion to interact with or confound the parameters under investigation
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No potential for confounded findings due to psychological stress physiology
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Potential for confounded findings due to physiological stress physiology
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Directly translatable to clinical studies
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Difficulty with translation to clinical studies
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