Fig. 4

Glucose challenge results for 3- and 7-month-old rats. Plasma glucose and insulin levels were measured at baseline, 30 min and 60 min after the glucose tolerance test. a Plasma glucose levels in 3-month-old spontaneously hypertensive rats (SHR, continuous line + black circle) and Wistar Kyoto controls (WKY, dashed line + white circle); b plasma glucose levels in 7-month-old SHRs and controls; c plasma insulin levels in 3-month-old SHRs and controls; d plasma insulin levels in 7-month-old SHRs and controls; e-f Area under the curve (AUC) of glucose and insulin values from the oral glucose tolerance test (OGTT) of SHR and WKY in 3- and 7-months old animals (points & lines bars, respectively). Bars represent the mean ± SEM. Significant differences were based on the ANOVA Post-Hoc Scheffé; *p < 0.05 vs. baseline control; **p < 0.05 vs. baseline SHR; ***p < 0.05 vs. 60 min control; + p < 0.05 vs. 30 min control; (e & f) + p < 0.05; ++ p < 0.01; n = 10