Table 1 Most significant pathways and networks identified by IPA of genes showing significant (p < 0.001) promoter hypermethylation (A) and hypomethylation (B) of the schizophrenia affected vs. healthy monozygotic twins in twin pair 1

HIPPO signaling

3.93E-03

4/85 (0.047)

MAPK Signaling

4.27E-03

4/87 (0.046)

Molecular and Cellular Functions

Cell Cycle, DNA Replication, Recombination

1.69E-04–1.51E-02

6

Cellular development, growth and proliferation

1.16E-03–4.45E-02

24

Cell Death and Survival

1.67E-03–4.54E-02

22

Diseases and Disorders

Developmental disorder

3.56E-03–4.72E-02

16

Hereditary disorder

3.56E-03–2.99E-02

22

Organismal injury and abnormalities

3.56E-03–4.91E-02

45

Most Significant Networks

#of molecules

Cellular Growth, Proliferation, Cellular movement & development

131

Cell Death and Survival, Cellular movement

69

Canonical Pathways

P-value

Ratio^a

Dopamine-DARPP32 feedback in cAMP signaling

7.43E-03

6/157 (0.038)

Calcium Signalling

1.08E-02

6/170 (0.035)

Ephrin Receptor Signalling

1.13E-02

6/172 (0.035)

Molecular and Cellular Functions

Gene expression

3.75E-04–4.97E-02

37

Cellular Assembly and Organization

1.15E-03–4.61E-02

22

Small Molecule Biochemistry

3.39E-03–4.51E-02

16

Lipid Metabolism

3.39E-03–3.69E-02

6

Diseases and disorders

# of molecules

Metabolic disease

3.38E-04–4.28E-02

17

Endocrine system disorders

1.95E-04–4.42E-02

21

Nervous system development and function

1.71E-03–4.28E-02

3

Most Significant Networks

Cell-mediated Immune Response, Cellular Movement

60

Cell Cycle, Cellular Development

56