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Table 1 Most significant pathways and networks identified by IPA of genes showing significant (p < 0.001) promoter hypermethylation (A) and hypomethylation (B) of the schizophrenia affected vs. healthy monozygotic twins in twin pair 1

From: Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia

Canonical Pathways P-value Ratioa
HIPPO signaling 3.93E-03 4/85 (0.047)
MAPK Signaling 4.27E-03 4/87 (0.046)
Molecular and Cellular Functions   
Cell Cycle, DNA Replication, Recombination 1.69E-04–1.51E-02 6
Cellular development, growth and proliferation 1.16E-03–4.45E-02 24
Cell Death and Survival 1.67E-03–4.54E-02 22
Diseases and Disorders   
Developmental disorder 3.56E-03–4.72E-02 16
Hereditary disorder 3.56E-03–2.99E-02 22
Organismal injury and abnormalities 3.56E-03–4.91E-02 45
Most Significant Networks   #of molecules
Cellular Growth, Proliferation, Cellular movement & development   131
Cell Death and Survival, Cellular movement   69
Canonical Pathways P-value Ratioa
Dopamine-DARPP32 feedback in cAMP signaling 7.43E-03 6/157 (0.038)
Calcium Signalling 1.08E-02 6/170 (0.035)
Ephrin Receptor Signalling 1.13E-02 6/172 (0.035)
Molecular and Cellular Functions   
Gene expression 3.75E-04–4.97E-02 37
Cellular Assembly and Organization 1.15E-03–4.61E-02 22
Small Molecule Biochemistry 3.39E-03–4.51E-02 16
Lipid Metabolism 3.39E-03–3.69E-02 6
Diseases and disorders   # of molecules
Metabolic disease 3.38E-04–4.28E-02 17
Endocrine system disorders 1.95E-04–4.42E-02 21
Nervous system development and function 1.71E-03–4.28E-02 3
Most Significant Networks   
Cell-mediated Immune Response, Cellular Movement   60
Cell Cycle, Cellular Development   56
  1. aThe number of molecules that reach the threshold of significant methylation difference between twins
  2. (Peak score > =3.1)