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Table 2 Most significant pathways and networks identified by IPA of genes showing significant (p < 0.001) promoter hypermethylation (A) and hypomethylation (B) of the schizophrenia affected vs. healthy monozygotic twins in twin pair 2

From: Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia

A)
Canonical Pathways P-value Ratioa
Triacylglycerol Biosynthesis 2.94E-03 4/33 (0.121)
Phosphatidylglycerol Biosynthesis II 3.39E-03 3/17 (0.176)
Molecular and Cellular Functions   
Gene Expression 5.79E-06–3.62E-02 53
Cellular Movement 9.84E-04–4.83E-02 19
Molecular transport and protein trafficking 4.01E-03–4.39E-03 16
Diseases and disorders   
Developmental disorder 9.84E-04–4.10E-02 36
Hereditary disorder 9.84E-04–3.77E-02 46
Most Significant Networks   # of molecules
Cell Death and Survival, Cellular Growth   47
Cellular Movement, Immune Cell Trafficking   45
B)
Canonical Pathways P-value Ratioa
Glutamate Receptor Signaling 1.05E-02 4/56 (0.071)
CREB Signalling in Neurons 1.53E-02 7/169 (0.041)
Molecular and Cellular Functions   
Cell Signalling 4.34E-06–4.51E-02 18
Nucleic Acid Metabolism 4.34E-06–4.51E-02 16
Small Molecular Biochemistry 4.34E-06–4.51E-02 29
Diseases and disorders   
Cell death and survival 3.55E-06–4.76E-02 141
Inflammatory disease 3.35E-03–4.59E-02 18
Most Significant Networks   # of molecules
Cellular Movement, Immune Cell Trafficking   64
Cell Death and Survival, Cell Cycle, Embryonic Development   45
Cellular Movement, Cellular Growth and Proliferation, cell morphology   44
  1. aThe number of molecules that reach the threshold of significant methylation difference between twins
  2. (Peak score > =3.1)