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Fig. 3 | Journal of Molecular Psychiatry

Fig. 3

From: Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy

Fig. 3

“A systems biological program for prevention and therapy of AD”. In order to support our genetic programs’ “interest” in maintaining lifelong mental health, the primary measures to prevent AD consist of a rich social life, daily new challenges which provide eustress and memorable experiences, physical activity and sufficient deep sleep, and adequate amounts of essential nutrients. As indicated by the green lines (and outlined in the main text), each of these measures have positive impacts, directly or indirectly, on key physiological systems or processes required for the preservation of mental health. In the case of an AD-diagnosis, these systems are not only compromised but, as outlined in Fig. 2 and detailed in the main text, lead to runaway phenomena. Hence, in addition to the implementation of the preventive measures and the correction of lifestyle-caused deficiencies, the proposed therapeutic interventions consist of a systemic combination of active components that were shown to interrupt the various vicious cycles that drive and accelerate the AD process. Each one was selected by its ability to interfere with a particular key pathophysiological process. But as indicated by the red lines and as outlined in detail in the main text, all of the suggested active components help to reactivate a variety of functions that are disturbed by the AD process

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